When a grocery clerk commits an impossible assassination, the government calls in Dr. Lee Rosen and his team of "Alphas": unique individuals with neurological mutations that give them special abilities. The team must determine who the killer is and track him down, but soon discover that a greater plan is in motion.
While trying to thwart a Red Flag operation, Rosen and his team find a captive woman, Anna, who can translate any language. While the others try to track down the Red Flag leader, Gary bonds with Anna over their similar conditions.
A young Alpha with the ability to create powerful inventions from common items goes missing, and Rosen and his team are called upon to find her... and protect her. Meanwhile, Gary challenges his mother and Bill contemplates fatherhood.